Ntchito Yodabwitsa ya Hyperbaric Oxygen Therapy mu Cardiovascular Health

Kutulutsa Mphamvu ya Physical Oxygen Supply

Kafukufuku akuwonetsa kuti mkati mwa chipinda cha hyperbaric pa 2 atmospheres of pressure (hyperbaric chamber 2 ata), kusungunuka kwa okosijeni kumakhala kokulirapo kuwirikiza kakhumi kuposa momwe zimakhalira. Mayamwidwe owonjezerekawa amathandizira kuti mpweya ulowe m'malo otsekeka oyenda magazi, ndikubweretsa "oxygen wadzidzidzi" ku mtima wa ischemic kapena minofu yaubongo. Njirayi imakhala yopindulitsa makamaka kwa anthu omwe akudwala hypoxia yosatha chifukwa cha mikhalidwe monga coronary artery stenosis ndi cerebral arteriosclerosis, zomwe zimapereka mpumulo mwachangu kuzizindikiro monga kulimba pachifuwa ndi chizungulire.

 

Kupititsa patsogolo Angiogenesisndi Kumanganso Njira za Oxygen

Chithandizo cha okosijeni cha hyperbaric sichimangoyang'ana zofunikira zachangu komanso chimalimbikitsa kuchira kwa nthawi yayitali polimbikitsa kutulutsidwa kwa vascular endothelial growth factor (VEGF). Njirayi imathandizira kuti pakhale kufalikira kwa chikole m'madera a ischemic, kupititsa patsogolo kwambiri magazi kumtima ndi ubongo. Kafukufuku wasonyeza kuti pambuyo magawo 20 HBOT, odwala matenda a mtsempha wamagazi kuona kuwonjezeka mochititsa chidwi m`mnyewa wamtima microcirculation ndi 30% mpaka 50%.

 

Anti-inflammatory and Antioxidant Effects: Kuteteza Ntchito Yama cell

Kuphatikiza pa kuthekera kwake kwa okosijeni, HBOT imakhala ndi anti-yotupa komanso antioxidant zotsatira, zomwe zimapangitsa kuti zikhale zofunika kwambiri kuteteza mtima ndi magwiridwe antchito a ubongo. Kafukufuku akuwonetsa kuti mankhwalawa amatha kupondereza njira zotupa monga NF-κB, kuchepetsa kutulutsidwa kwa zinthu zoyambitsa kutupa monga TNF-α ndi IL-6. Kuphatikiza apo, kupititsa patsogolo ntchito ya superoxide dismutase (SOD) kumathandizira kuthetsa ma radicals aulere, kuchepetsa kuwonongeka kwa endothelial ndikupereka chitetezo ku matenda osachiritsika monga atherosclerosis ndi kusintha kwa mitsempha yamagazi.

 

Clinical Applications of Hyperbaric Oxygen mu Cardiovascular Diseases

Zochitika Zowopsa za Ischemic

Myocardial Infarction: Ikagwiritsidwa ntchito limodzi ndi thrombolysis kapena mankhwala ochiritsira, HBOT imatha kuchepetsa apoptosis ya myocardial cell ndikuchepetsa chiopsezo cha matenda owopsa a arrhythmias.

Cerebral Infarction: Kugwiritsa ntchito koyambirira kwa hyperbaric oxygen therapy kumatha kutalikitsa moyo wa maselo, kuchepetsa kukula kwa infarct, ndi kupititsa patsogolo ntchito zamanjenje.

 

Kubwezeretsa Matenda Osatha

Stable Coronary Artery Disease: Odwala nthawi zambiri amakhala ndi zizindikiro za angina, kuwonjezeka kwa masewera olimbitsa thupi, komanso kuchepetsa kudalira mankhwala a nitrate.

Rapid Atrial Arrhythmias (Slow Type): Kupyolera mu zotsatira zoipa za inotropic, HBOT imathandiza kuchepetsa kugunda kwa mtima, kuchepetsa kugwiritsira ntchito okosijeni wa myocardial, ndi kukonzanso mikhalidwe ya ischemic.

Matenda a Mtima Wothamanga Kwambiri: Mankhwalawa amachepetsa kukhuthala kwa magazi ndikuchepetsa kumanzere kwa ventricular hypertrophy, zomwe zimachepetsa kukula kwa mtima kulephera.

Post-Stroke Sequelae: HBOT imathandizira kukonzanso kwa synaptic, kupititsa patsogolo ntchito zamagalimoto ndi luso lazidziwitso.

 

Mbiri Yachitetezo cha Hyperbaric Oxygen Therapy

HBOT nthawi zambiri imawonedwa ngati yotetezeka, yokhala ndi zotsatirapo zochepa. Zomwe zimadetsa nkhawa kwambiri ndizovuta zapakatikati za khutu, zomwe zimatha kuchepetsedwa ndikusintha kuthamanga. Komabe, pali zotsutsana zenizeni, kuphatikizapo kutaya magazi, pneumothorax yosachiritsika, emphysema yoopsa, pulmonary bullae, ndi chipika chonse cha mtima.

 

Chiyembekezo cha M'tsogolo: Kuyambira Kuchiza Mpaka Kupewa

Kafukufuku waposachedwa akuwonetsa kuthekera kwa HBOT pakuchedwetsa njira ya atherosclerotic mwa kuwongolera kukhazikika kwa mtima komanso kutsitsa lipids m'magazi. Izi zimayika okosijeni wa hyperbaric ngati njira yolimbikitsira polimbana ndi "hypoxia yopanda phokoso," makamaka mwa anthu omwe ali ndi zizindikiro monga chizungulire, kuchepa kwa kukumbukira, ndi kusowa tulo. Ndi kupita patsogolo kwa chithandizo chamankhwala chothandizidwa ndi AI komanso kugwiritsa ntchito mwatsopano monga stem cell therapy, HBOT ikuyenera kukhala pachimake pakukula kwaumoyo wamtima.

 

Mapeto

Chithandizo cha okosijeni cha hyperbaric chimadziwika ngati njira yodalirika, yopanda mankhwala ya matenda a mtima, yomangidwa pamaziko a "oksijeni wakuthupi." Njira yowonjezerekayi, kuphatikiza kukonzanso kwa mitsempha, zotsatira zotsutsa-kutupa, ndi zopindulitsa za antioxidant, zimasonyeza ubwino wochuluka pazochitika zadzidzidzi komanso kukonzanso kosatha. Komanso, kugwiritsa ntchito electrocardiograms (ECG) monga chizindikiro chodziwika bwino cha oxygenation ndi ischemia ikhoza kukhala umboni wachipatala wothandiza kwambiri wa HBOT. Kusankha HBOT sikungosankha chithandizo; kumatanthauza kudzipereka kwachangu pakuwongolera thanzi ndi moyo wamunthu.