Stroke, vuto lowononga lomwe limadziwika ndi kuchepa kwadzidzidzi kwa magazi ku minofu ya muubongo chifukwa cha matenda a hemorrhagic kapena ischemic pathology, ndi chachiwiri chomwe chimayambitsa imfa padziko lonse lapansi komanso chachitatu chomwe chimayambitsa kulumala. Mitundu iwiri yayikulu ya sitiroko ndi ischemic stroke (yowerengera 68%) ndi hemorrhagic stroke (32%). Ngakhale ma pathophysiology awo amasiyana m'magawo oyambilira, onsewa amabweretsa kuchepa kwa magazi komanso cerebral ischemia panthawi ya subacute komanso matenda.
Ischemic Stroke
Ischemic stroke (AIS) imadziwika ndi kutsekeka kwadzidzidzi kwa mtsempha wamagazi, zomwe zimapangitsa kuwonongeka kwa ischemic kudera lomwe lakhudzidwa. Mu gawo lovuta kwambiri, chilengedwe choyambirira cha hypoxic ichi chimayambitsa kuchulukira kwa chisangalalo, kupsinjika kwa okosijeni, ndi kuyambitsa kwa microglia, zomwe zimayambitsa kufa kwa neuronal. Pa gawo la subacute, kutulutsidwa kwa ma cytokines, chemokines, ndi matrix metalloproteinases (MMPs) kumatha kupangitsa neuroinflammation. Mwachidziwitso, milingo yokwera ya ma MMP imawonjezera kufalikira kwa chotchinga chamagazi-ubongo (BBB), kulola kuti leukocyte isamuke m'dera losakhazikika, kukulitsa ntchito yotupa.
Chithandizo Chamakono cha Ischemic Stroke
Chithandizo choyambirira cha AIS chimaphatikizapo thrombolysis ndi thrombectomy. Mtsempha wa thrombolysis ukhoza kupindulitsa odwala mkati mwa maola 4.5, pomwe chithandizo cham'mbuyo chimatanthawuza ubwino waukulu. Poyerekeza ndi thrombolysis, thrombectomy yamakina imakhala ndi zenera lazachipatala. Komanso, sanali pharmacological, sanali invasive mankhwala mongamankhwala okosijeni, kutema mphini, ndi kusonkhezeredwa ndi magetsi akuwonjezereka monga machiritso ochiritsira ku njira wamba.
Zofunikira za Hyperbaric Oxygen Therapy (HBOT)
Kuthamanga kwa nyanja (1 ATA = 101.3 kPa), mpweya umene timapuma umakhala ndi pafupifupi 21% oxygen. Pansi pa zochitika za thupi, gawo la mpweya wosungunuka mu plasma ndi lochepa, pafupifupi 0.29 mL (0.3%) pa 100 ml ya magazi. Pansi pa hyperbaric mikhalidwe, kutulutsa mpweya wa 100% kumawonjezera mpweya wosungunuka mu plasma kwambiri-mpaka 3.26% pa 1.5 ATA ndi 5.6% pa 2.5 ATA. Chifukwa chake, HBOT ikufuna kupititsa patsogolo gawo ili la okosijeni wosungunuka, moyenerakuonjezera kuchuluka kwa oxygen m'magawo a ischemic. Pazovuta kwambiri, mpweya umafalikira mosavuta m'magulu a hypoxic, kufika pamtunda wautali wotalikirana poyerekeza ndi kuthamanga kwa mumlengalenga.
Mpaka pano, HBOT yawona kugwiritsidwa ntchito kofala kwa zikwapu za ischemic ndi hemorrhagic. Kafukufuku akuwonetsa kuti HBOT imapereka zotsatira za neuroprotective kudzera munjira zingapo zovuta zama cell, biochemical, ndi hemodynamic, kuphatikiza:
1. Kuchuluka kwa mpweya wa okosijeni pang'ono, kupititsa patsogolo kutumizidwa kwa okosijeni ku minofu ya ubongo.
2. Kukhazikika kwa BBB, kuchepetsa edema ya ubongo.
3. Kupititsa patsogolo ubongomicrocirculation, kukonza kagayidwe muubongo ndi kupanga mphamvu ndikusunga ma cell ion homeostasis.
4. Kuwongolera kuyenda kwa magazi muubongo kuti muchepetse kuthamanga kwa intracranial komanso kuchepetsa kutupa muubongo.
5. Kuchepetsa kwa neuroinflammation pambuyo pa sitiroko.
6. Kuchepetsa apoptosis ndi necrosiskutsatira sitiroko.
7. Kuchepetsa kupsinjika kwa okosijeni ndi kuletsa kuvulala kobwerezabwereza, kofunika kwambiri pa matenda a stroke.
8. Kafukufuku akusonyeza kuti HBOT ikhoza kuchepetsa vasospasm kutsatira aneurysmal subarachnoid hemorrhage (SAH).
9. Umboni umathandizanso phindu la HBOT polimbikitsa neurogenesis ndi angiogenesis.
Mapeto
Hyperbaric oxygen therapy imapereka njira yodalirika yochizira sitiroko. Pamene tikupitiriza kufotokoza zovuta za kuchira kwa sitiroko, kufufuza kwina kudzakhala kofunikira kuti timvetsetse bwino nthawi, mlingo, ndi njira za HBOT.
Mwachidule, pamene tikufufuza ubwino wa hyperbaric oxygen therapy chifukwa cha sitiroko, zikuwonekeratu kuti kugwiritsa ntchito mankhwalawa kungathe kusintha momwe timayendetsera zikwapu za ischemic, kupereka chiyembekezo kwa omwe akukhudzidwa ndi vutoli.
Ngati mukufuna kudziwa za hyperbaric oxygen therapy ngati chithandizo chothandizira kuchira, tikukupemphani kuti mupite kutsamba lathu kuti mudziwe zambiri za zipinda zathu zapamwamba za hyperbaric oxygen. Ndi mitundu ingapo yopangidwa kuti igwiritsidwe ntchito kunyumba ndi akatswiri, MACY-PAN imapereka mayankho omwe amapereka chithandizo chapamwamba kwambiri cha okosijeni kuti chithandizire ulendo wanu wathanzi ndi kuchira.
Dziwani zogulitsa zathu ndi momwe zingakuthandizireni kukhala ndi moyo wabwinowww.hbotmacypan.com.
Nthawi yotumiza: Feb-18-2025