Mu mankhwala amakono, maantibayotiki atsimikizira kuti ndi chimodzi mwa zinthu zofunika kwambiri, zomwe zachepetsa kwambiri kuchuluka kwa anthu omwe amafa chifukwa cha matenda opatsirana pogwiritsa ntchito mabakiteriya. Kutha kwawo kusintha zotsatira zachipatala za matenda opatsirana pogwiritsa ntchito mabakiteriya kwawonjezera nthawi ya moyo wa odwala ambiri. Maantibayotiki ndi ofunikira kwambiri pa njira zovuta zachipatala, kuphatikizapo opaleshoni, kuika zinthu zoikidwa m'thupi, kuziika m'thupi, ndi chemotherapy. Komabe, kubuka kwa tizilombo toyambitsa matenda tosagwiritsa ntchito maantibayotiki kwakhala nkhawa yomwe ikukulirakulira, zomwe zikuchepetsa mphamvu ya mankhwala amenewa pakapita nthawi. Zochitika za kukana maantibayotiki zalembedwa m'magulu onse a maantibayotiki pamene kusintha kwa mabakiteriya kumachitika. Kupanikizika kosankhidwa kwa mankhwala opha tizilombo kwathandizira kukwera kwa mitundu yosagwiritsa ntchito maantibayotiki, zomwe zikubweretsa vuto lalikulu pa thanzi la anthu padziko lonse lapansi.
Pofuna kuthana ndi vuto lalikulu la kukana maantibayotiki, ndikofunikira kukhazikitsa mfundo zogwira mtima zowongolera matenda zomwe zimachepetsa kufalikira kwa tizilombo toyambitsa matenda tosagonjetsedwa, komanso kuchepetsa kugwiritsa ntchito maantibayotiki. Kuphatikiza apo, pali kufunika kwakukulu kwa njira zina zochiritsira. Hyperbaric Oxygen Therapy (HBOT) yakhala njira yabwino kwambiri pankhani iyi, yokhudza kupuma mpweya wa 100% pamlingo winawake wa kuthamanga kwa magazi kwa nthawi ndithu. Pokhala ngati chithandizo choyamba kapena chowonjezera cha matenda, HBOT ikhoza kupereka chiyembekezo chatsopano pakuchiza matenda opatsirana omwe amayamba chifukwa cha tizilombo toyambitsa matenda tosagonjetsedwa ndi maantibayotiki.
Mankhwalawa akugwiritsidwa ntchito kwambiri ngati chithandizo choyamba kapena china pa matenda osiyanasiyana, kuphatikizapo kutupa, poizoni wa carbon monoxide, mabala osatha, matenda a ischemic, ndi matenda opatsirana. Kugwiritsa ntchito kwa HBOT kuchipatala pochiza matenda n'kofunika kwambiri, ndipo kumapereka ubwino wofunika kwambiri kwa odwala.
Kugwiritsa Ntchito Mankhwala Ochepetsa Mpweya wa Hyperbaric mu Matenda
Umboni wamakono umatsimikizira kwambiri kugwiritsa ntchito HBOT, monga chithandizo chodziyimira pawokha komanso chowonjezera, zomwe zimabweretsa zabwino zazikulu kwa odwala omwe ali ndi kachilomboka. Panthawi ya HBOT, kuthamanga kwa mpweya m'magazi kumatha kukwera kufika pa 2000 mmHg, ndipo kuchuluka kwa mpweya m'thupi kumatha kukweza kuchuluka kwa mpweya m'thupi kufika pa 500 mmHg. Zotsatirazi ndizofunika kwambiri polimbikitsa kuchira kwa kutupa ndi kusokonezeka kwa magazi m'thupi komwe kumachitika m'malo ozungulira, komanso poyang'anira matenda a compartment syndrome.
HBOT ingakhudzenso matenda omwe amadalira chitetezo chamthupi. Kafukufuku akusonyeza kuti HBOT imatha kuletsa matenda a autoimmune syndromes ndi mayankho a chitetezo chamthupi omwe amayambitsidwa ndi antigen, zomwe zimathandiza kusunga kulekerera kwa graft mwa kuchepetsa kufalikira kwa ma lymphocyte ndi ma leukocyte pomwe ikusintha mayankho a chitetezo chamthupi. Kuphatikiza apo, HBOTzimathandiza kuchiritsamu zilonda za pakhungu zosatha mwa kulimbikitsa angiogenesis, njira yofunika kwambiri yochiritsira bwino. Mankhwalawa amalimbikitsanso kupanga collagen matrix, gawo lofunikira pakuchiritsa mabala.
Chisamaliro chapadera chiyenera kuperekedwa ku matenda ena, makamaka matenda akuya komanso ovuta kuchiza monga necrotizing fasciitis, osteomyelitis, matenda osatha a minofu yofewa, ndi matenda opatsirana a endocarditis. Chimodzi mwa ntchito zodziwika bwino za HBOT ndi matenda a minofu yofewa ngati khungu ndi osteomyelitis yokhudzana ndi mpweya wochepa womwe nthawi zambiri umayamba chifukwa cha mabakiteriya osagwira ntchito kapena osagwira ntchito.
1. Matenda a Matenda a Shuga ku Mapazi
Phazi la matenda a shugaZilonda zam'mimba ndi vuto lofala pakati pa odwala matenda a shuga, lomwe limakhudza anthu okwana 25% mwa anthuwa. Matendawa nthawi zambiri amapezeka m'zilondazi (zomwe zimapangitsa kuti 40%-80% ya milandu ichitike) ndipo zimapangitsa kuti anthu ambiri azidwala komanso kufa. Matenda a mapazi a shuga (DFIs) nthawi zambiri amakhala ndi matenda a tizilombo toyambitsa matenda omwe mabakiteriya osiyanasiyana omwe amapezeka ndi mabakiteriya omwe alibe mphamvu yamagetsi. Zinthu zosiyanasiyana, kuphatikizapo zolakwika pa ntchito ya fibroblast, mavuto opangidwa ndi collagen, njira zodzitetezera ku matenda a m'thupi, ndi ntchito ya phagocyte, zimatha kulepheretsa kuchira kwa mabala mwa odwala matenda a shuga. Kafukufuku wambiri wapeza kuti kufooka kwa mpweya m'khungu ndi chinthu chomwe chimayambitsa kudulidwa ziwalo zokhudzana ndi ma DFI.
Monga njira imodzi yomwe ilipo yochizira DFI, HBOT yanenedwa kuti ikukweza kwambiri kuchuluka kwa machiritso a zilonda za mapazi za matenda ashuga, kenako kuchepetsa kufunika kodulidwa ziwalo ndi njira zovuta zochitira opaleshoni. Sikuti imangochepetsa kufunikira kwa njira zogwiritsira ntchito zinthu zambiri, monga opaleshoni yolumikizira mphuno ndi kuyika chikopa pakhungu, komanso imapereka ndalama zochepa komanso zotsatirapo zochepa poyerekeza ndi njira zina zochitira opaleshoni. Kafukufuku wochitidwa ndi Chen et al. adawonetsa kuti magawo opitilira 10 a HBOT adapangitsa kuti chiwopsezo cha machiritso a mabala chiwonjezeke ndi 78.3% mwa odwala matenda ashuga.
2. Matenda Ofewa a Minofu Yofewa
Matenda opatsirana ndi minofu yofewa (NSTIs) nthawi zambiri amakhala ndi tizilombo toyambitsa matenda tomwe timayambitsa matenda osiyanasiyana, omwe nthawi zambiri amachokera ku kuphatikiza kwa tizilombo toyambitsa matenda tomwe timayambitsa matenda a aerobic ndi anaerobic ndipo nthawi zambiri amagwirizanitsidwa ndi kupanga mpweya. Ngakhale kuti matenda a NSTI ndi osowa kwambiri, amapha anthu ambiri chifukwa cha kupita patsogolo kwawo mwachangu. Kuzindikira ndi kulandira chithandizo panthawi yake komanso moyenera ndikofunikira kwambiri kuti tipeze zotsatira zabwino, ndipo HBOT yalimbikitsidwa ngati njira yowonjezera yothanirana ndi matenda a NSTI. Ngakhale kuti pakadalibe kutsutsana pankhani yogwiritsira ntchito HBOT mu matenda a NSTI chifukwa cha kusowa kwa maphunziro olamulidwa,Umboni ukusonyeza kuti izi zitha kukhala zogwirizana ndi kuchuluka kwa kupulumuka komanso kusungidwa kwa ziwalo mwa odwala a NSTIKafukufuku wobwerezabwereza adawonetsa kuchepa kwakukulu kwa chiwerengero cha imfa pakati pa odwala a NSTI omwe amalandira HBOT.
1.3 Matenda Okhudza Malo Ochitira Opaleshoni
Ma SSI amatha kugawidwa m'magulu kutengera malo omwe kachilomboka kali ndipo amatha kuchokera ku tizilombo toyambitsa matenda osiyanasiyana, kuphatikizapo mabakiteriya a aerobic ndi anaerobic. Ngakhale kuti pakhala kupita patsogolo pa njira zowongolera matenda, monga njira zoyeretsera, kugwiritsa ntchito maantibayotiki oletsa matenda, komanso kupititsa patsogolo njira zochitira opaleshoni, ma SSI akadali vuto lopitirira.
Ndemanga imodzi yofunika yafufuza momwe HBOT imagwirira ntchito popewa ma SSI ozama mu opaleshoni ya neuromuscular scoliosis. HBOT isanachitidwe opaleshoni ingachepetse kwambiri kuchuluka kwa ma SSI ndikuthandizira kuchira kwa mabala. Mankhwala osalowa m'thupi awa amapanga malo omwe kuchuluka kwa okosijeni m'maselo a mabala kumakwera, zomwe zagwirizanitsidwa ndi kupha kwa okosijeni motsutsana ndi tizilombo toyambitsa matenda. Kuphatikiza apo, imayang'ana kuchepa kwa magazi ndi mpweya zomwe zimathandizira pakukula kwa ma SSI. Kupatula njira zina zowongolera matenda, HBOT yalimbikitsidwa makamaka pa maopaleshoni oyera monga njira zochizira matenda a m'matumbo.
1.4 Kupsa
Kupsa ndi kuvulala komwe kumachitika chifukwa cha kutentha kwambiri, mphamvu yamagetsi, mankhwala, kapena kuwala kwa dzuwa ndipo kumatha kuyambitsa matenda ambiri komanso kufa. HBOT ndi yothandiza pochiza kupsa mwa kuwonjezera mpweya m'thupi lomwe lawonongeka. Ngakhale maphunziro a nyama ndi azachipatala akuwonetsa zotsatira zosiyanasiyana zokhudzana ndiKugwira ntchito kwa HBOT pochiza kupsa, kafukufuku wokhudza odwala 125 opsa mtima adawonetsa kuti HBOT sinakhudze kwambiri kuchuluka kwa imfa kapena kuchuluka kwa maopaleshoni omwe adachitidwa koma idachepetsa nthawi yochira (masiku 19.7 poyerekeza ndi masiku 43.8). Kuphatikiza HBOT ndi kasamalidwe kathunthu ka kupsa mtima kungachepetse bwino sepsis mwa odwala opsa mtima, zomwe zimapangitsa kuti nthawi yochira ikhale yochepa komanso kuchepetsa kufunikira kwa madzi. Komabe, kafukufuku wowonjezereka wowonjezereka akufunika kuti atsimikizire udindo wa HBOT pakuwongolera kupsa mtima kwakukulu.
1.5 Matenda a Osteomyelitis
Osteomyelitis ndi matenda a mafupa kapena mafupa omwe nthawi zambiri amayamba chifukwa cha tizilombo toyambitsa matenda. Kuchiza osteomyelitis kungakhale kovuta chifukwa cha kuchepa kwa magazi m'mafupa komanso kuchepa kwa maantibayotiki kulowa m'mafupa. Osteomyelitis yosatha imadziwika ndi tizilombo toyambitsa matenda tomwe timakhalapo nthawi zonse, kutupa pang'ono, komanso kupangika kwa minofu ya mafupa. Osteomyelitis yosakhazikika imatanthauza matenda a mafupa osatha omwe amapitirira kapena kubwereranso ngakhale atalandira chithandizo choyenera.
HBOT yawonetsedwa kuti imakweza kwambiri kuchuluka kwa mpweya m'mafupa omwe ali ndi kachilomboka. Kafukufuku wambiri komanso kafukufuku wamagulu osiyanasiyana akuwonetsa kuti HBOT imawonjezera zotsatira zachipatala kwa odwala matenda a osteomyelitis. Zikuoneka kuti imagwira ntchito kudzera m'njira zosiyanasiyana, kuphatikizapo kukulitsa kagayidwe kachakudya m'thupi, kuletsa tizilombo toyambitsa matenda, kuwonjezera mphamvu ya maantibayotiki, kuchepetsa kutupa, komanso kulimbikitsa machiritso.njira. Pambuyo pa HBOT, 60% mpaka 85% ya odwala omwe ali ndi matenda osatha komanso osagwirizana ndi mafupa a m'chiuno amasonyeza zizindikiro za kufooka kwa matenda.
1.6 Matenda a Bowa
Padziko lonse lapansi, anthu opitilira mamiliyoni atatu amadwala matenda a bowa osatha kapena olowa m'thupi, zomwe zimapangitsa kuti anthu opitilira 600,000 afe pachaka. Zotsatira za chithandizo cha matenda a bowa nthawi zambiri zimachepa chifukwa cha zinthu monga kusintha kwa chitetezo cha mthupi, matenda oyamba, komanso momwe tizilombo toyambitsa matenda timafalikira. HBOT ikukhala njira yothandiza kwambiri pochiza matenda akuluakulu a bowa chifukwa cha chitetezo chake komanso momwe sichimalowa m'thupi. Kafukufuku akusonyeza kuti HBOT ikhoza kukhala yothandiza polimbana ndi matenda a bowa monga Aspergillus ndi Mycobacterium TB.
HBOT imalimbikitsa mphamvu ya bowa poletsa kupangika kwa Aspergillus m'thupi, ndipo mphamvu yowonjezera imawonedwa m'mitundu yopanda majini a superoxide dismutase (SOD). Matenda a bowa omwe amakhala ndi mpweya woipa nthawi ya matenda a bowa amachititsa kuti pakhale zovuta pakupereka mankhwala ophera bowa, zomwe zimapangitsa kuti mpweya wochuluka wochokera ku HBOT ukhale wothandiza, ngakhale kuti kafukufuku wowonjezereka ukufunika.
Katundu wa HBOT Woletsa Mabakiteriya
Malo okhala ndi okosijeni ambiri omwe amapangidwa ndi HBOT amayambitsa kusintha kwa thupi ndi kwa biochemical komwe kumalimbikitsa mphamvu zotsutsana ndi mabakiteriya, zomwe zimapangitsa kuti ikhale njira yothandiza yothandizira matenda. HBOT imasonyeza zotsatira zodabwitsa motsutsana ndi mabakiteriya othamanga komanso mabakiteriya omwe ali ndi mpweya wambiri kudzera mu njira monga kugwira ntchito mwachindunji kwa mabakiteriya, kuwonjezera mphamvu ya chitetezo cha mthupi, komanso zotsatira zogwirizana ndi mankhwala enaake oletsa mabakiteriya.
2.1 Zotsatira za HBOT Zokhudza Mabakiteriya Mwachindunji
Mphamvu yolimbana ndi mabakiteriya ya HBOT imakhudzidwa kwambiri ndi kupanga mitundu ya okosijeni yogwira ntchito (ROS), yomwe imaphatikizapo ma superoxide anions, hydrogen peroxide, hydroxyl radicals, ndi ma hydroxyl ions—zonsezi zimachitika panthawi ya kagayidwe ka maselo.
Kugwirizana pakati pa O₂ ndi zigawo za maselo ndikofunikira kuti timvetsetse momwe ROS imapangikira mkati mwa maselo. Pazifukwa zina zomwe zimatchedwa kupsinjika kwa okosijeni, kulinganiza pakati pa kupangika kwa ROS ndi kuwonongeka kwake kumasokonekera, zomwe zimapangitsa kuti ROS ikhale yokwera m'maselo. Kupanga kwa superoxide (O₂⁻) kumayendetsedwa ndi superoxide dismutase, yomwe pambuyo pake imasintha O₂⁻ kukhala hydrogen peroxide (H₂O₂). Kusinthaku kumakulitsidwanso ndi Fenton reaction, yomwe imapangitsa Fe²⁺ kupanga ma hydroxyl radicals (·OH) ndi Fe³⁺, motero kuyambitsa njira yowononga ya redox ya kupangika kwa ROS ndi kuwonongeka kwa maselo.
Zotsatira za poizoni za ROS zimakhudza zigawo zofunika kwambiri za maselo monga DNA, RNA, mapuloteni, ndi lipids. Chodziwika bwino n'chakuti, DNA ndiye cholinga chachikulu cha poizoni woyambitsidwa ndi H₂O₂, chifukwa imasokoneza kapangidwe ka deoxyribose ndikuwononga kapangidwe ka maziko. Kuwonongeka kwakuthupi komwe kumachitika ndi ROS kumafikira ku kapangidwe ka helix ka DNA, komwe mwina kumachitika chifukwa cha lipid peroxidation yomwe imayambitsidwa ndi ROS. Izi zikuwonetsa zotsatira zoyipa za kuchuluka kwa ROS m'machitidwe achilengedwe.
Ntchito ya ROS yolimbana ndi tizilombo toyambitsa matenda
ROS imagwira ntchito yofunika kwambiri poletsa kukula kwa tizilombo toyambitsa matenda, monga momwe zasonyezedwera kudzera mu kupanga kwa ROS komwe kumayambitsidwa ndi HBOT. Zotsatirapo za poizoni za ROS zimalunjika mwachindunji kuzinthu zomwe zili m'maselo monga DNA, mapuloteni, ndi mafuta. Kuchuluka kwa mitundu yogwira ntchito ya okosijeni kumatha kuwononga mafuta mwachindunji, zomwe zimapangitsa kuti mafuta azitha kulowa m'thupi. Njirayi imasokoneza umphumphu wa nembanemba ya maselo, motero, magwiridwe antchito a ma receptors ndi mapuloteni okhudzana ndi nembanemba.
Kuphatikiza apo, mapuloteni, omwe ndi ofunika kwambiri pa mamolekyu a ROS, amasinthidwa mwanjira inayake pa ma amino acid otsalira osiyanasiyana monga cysteine, methionine, tyrosine, phenylalanine, ndi tryptophan. Mwachitsanzo, HBOT yawonetsedwa kuti imayambitsa kusintha kwa ma oxidative m'mapuloteni angapo mu E. coli, kuphatikiza elongation factor G ndi DnaK, motero zimakhudza ntchito zawo zamaselo.
Kulimbitsa Chitetezo cha Mthupi Kudzera mu HBOT
Mphamvu zotsutsana ndi kutupa za HBOTzalembedwa, zomwe zikusonyeza kuti ndizofunikira kwambiri pochepetsa kuwonongeka kwa minofu ndikuletsa kupita patsogolo kwa matenda. HBOT imakhudza kwambiri kufotokozedwa kwa ma cytokines ndi ena olamulira kutupa, zomwe zimakhudza chitetezo chamthupi. Machitidwe osiyanasiyana oyesera adawona kusintha kosiyana kwa majini ndi kupanga mapuloteni pambuyo pa HBOT, zomwe zimakweza kapena kuchepetsa kukula kwa zinthu ndi ma cytokines.
Pa nthawi ya HBOT, kuchuluka kwa O₂ kumayambitsa mayankho osiyanasiyana a maselo, monga kuletsa kutulutsidwa kwa zinthu zoyambitsa kutupa komanso kulimbikitsa apoptosis ya lymphocyte ndi neutrophil. Zonsezi pamodzi, zochitazi zimawonjezera njira zodzitetezera ku matenda, motero zimathandiza kuchiritsa matenda.
Kuphatikiza apo, kafukufuku akusonyeza kuti kuchuluka kwa O₂ panthawi ya HBOT kungachepetse kufalikira kwa ma cytokines oyambitsa kutupa, kuphatikizapo interferon-gamma (IFN-γ), interleukin-1 (IL-1), ndi interleukin-6 (IL-6). Kusintha kumeneku kumaphatikizaponso kuchepetsa chiŵerengero cha maselo a CD4:CD8 T ndikusintha ma receptors ena osungunuka, zomwe pamapeto pake zimakweza kuchuluka kwa interleukin-10 (IL-10), komwe ndikofunikira kwambiri polimbana ndi kutupa ndikulimbikitsa machiritso.
Ntchito za HBOT zothana ndi mabakiteriya zimagwirizanitsidwa ndi njira zovuta zamoyo. Superoxide ndi kuthamanga kwa magazi kwanenedwa kuti zimathandizira ntchito yolimbana ndi mabakiteriya yomwe imabwera chifukwa cha HBOT komanso kufalikira kwa neutrophil. Pambuyo pa HBOT, kuchuluka kwa okosijeni m'magazi kumawonjezera mphamvu zopha mabakiteriya a neutrophils, gawo lofunikira kwambiri pa chitetezo chamthupi. Kuphatikiza apo, HBOT imaletsa kumatirira kwa neutrophil, komwe kumachitika chifukwa cha kuyanjana kwa β-integrins pa neutrophils ndi mamolekyulu omatirira a intercellular (ICAM) pa maselo a endothelial. HBOT imaletsa ntchito ya neutrophil β-2 integrin (Mac-1, CD11b/CD18) kudzera mu njira yothandizidwa ndi nitric oxide (NO), zomwe zimathandiza kuti ma neutrophils asamuke kupita kumalo omwe matenda afalikira.
Kukonzanso molondola kwa cytoskeleton ndikofunikira kuti ma neutrophils azitha kupha majeremusi bwino. S-nitrosylation ya actin yawonetsedwa kuti imalimbikitsa polymerization ya actin, zomwe zingathandize ntchito ya phagocytic ya ma neutrophils pambuyo pa chithandizo cha HBOT. Kuphatikiza apo, HBOT imalimbikitsa apoptosis m'mizere ya maselo a T a anthu kudzera m'njira za mitochondrial, ndipo kufa kwa lymphocyte mwachangu pambuyo pa HBOT kumanenedwa. Kutseka caspase-9—popanda kukhudza caspase-8—kwawonetsa zotsatira za HBOT zolimbitsa chitetezo chamthupi.
Zotsatira za HBOT ndi Mankhwala Oletsa Kutupa
Mu ntchito zachipatala, HBOT imagwiritsidwa ntchito nthawi zambiri pamodzi ndi maantibayotiki kuti athane ndi matenda moyenera. Mkhalidwe woopsa womwe umapezeka panthawi ya HBOT ukhoza kukhudza mphamvu ya maantibayotiki ena. Kafukufuku akusonyeza kuti mankhwala enaake opha mabakiteriya, monga β-lactams, fluoroquinolones, ndi aminoglycosides, samangogwira ntchito kudzera mu njira zobadwa nazo komanso amadalira pang'ono pa kagayidwe ka mabakiteriya. Chifukwa chake, kukhalapo kwa mpweya ndi kagayidwe ka mabakiteriya ndikofunikira kwambiri poyesa zotsatira za maantibayotiki.
Umboni wofunikira wasonyeza kuti mpweya wochepa umatha kuwonjezera kukana kwa Pseudomonas aeruginosa ku piperacillin/tazobactam ndipo mpweya wochepa umathandizanso kuti Enterobacter cloacae isagwirizane ndi azithromycin. Mosiyana ndi zimenezi, matenda ena a hypoxia angapangitse kuti mabakiteriya asamagwirizane ndi maantibayotiki a tetracycline. HBOT ndi njira yothandiza yothandizira pochiza matenda mwa kuyambitsa kagayidwe kachakudya m'thupi ndi kubwezeretsa mpweya m'thupi, zomwe zimapangitsa kuti tizilombo toyambitsa matenda tizigwirizana ndi maantibayotiki.
Mu maphunziro asanayambe chithandizo, kuphatikiza kwa HBOT—komwe kumaperekedwa kawiri patsiku kwa maola 8 pa 280 kPa—pamodzi ndi tobramycin (20 mg/kg/tsiku) kunachepetsa kwambiri kuchuluka kwa mabakiteriya mu Staphylococcus aureus infectious endocarditis. Izi zikusonyeza kuthekera kwa HBOT ngati chithandizo chothandizira. Kafukufuku wina wasonyeza kuti pansi pa 37°C ndi 3 ATA pressure kwa maola 5, HBOT inawonjezera kwambiri zotsatira za imipenem motsutsana ndi Pseudomonas aeruginosa yemwe ali ndi macrophage. Kuphatikiza apo, njira yophatikizana ya HBOT ndi cephazolin inapezeka kuti ndi yothandiza kwambiri pochiza Staphylococcus aureus osteomyelitis m'zinyama poyerekeza ndi cephazolin yokha.
HBOT imawonjezeranso kwambiri mphamvu ya ciprofloxacin yopha mabakiteriya motsutsana ndi Pseudomonas aeruginosa biofilms, makamaka pambuyo pa mphindi 90 kuchokera pamene yakhudzidwa. Kuwonjezeka kumeneku kumachitika chifukwa cha kupangika kwa mitundu ya okosijeni yogwira ntchito (ROS) ndipo kumawonetsa mphamvu yowonjezera mu ma mutants ofooka a peroxidase.
Mu zitsanzo za pleuritis yomwe imayambitsidwa ndi Staphylococcus aureus (MRSA) yokana methicillin, mphamvu yogwirizana ya vancomycin, teicoplanin, ndi linezolid yokhala ndi HBOT yawonetsa kuti yagwira ntchito bwino kwambiri motsutsana ndi MRSA. Metronidazole, mankhwala opha tizilombo omwe amagwiritsidwa ntchito kwambiri pochiza matenda oopsa a anaerobic ndi polymicrobial monga matenda a shuga m'mapazi (DFIs) ndi matenda opareshoni (SSIs), yawonetsa mphamvu yayikulu yopha tizilombo toyambitsa matenda pansi pa matenda a anaerobic. Maphunziro amtsogolo akuyenera kufufuza zotsatira za HBOT zotsutsana ndi mabakiteriya m'malo onse amkati ndi m'thupi.
Mphamvu ya HBOT Yolimbana ndi Mabakiteriya Osagonjetsedwa
Chifukwa cha kusintha ndi kufalikira kwa mitundu yosagonjetseka, maantibayotiki achikhalidwe nthawi zambiri amataya mphamvu zawo pakapita nthawi. Kuphatikiza apo, HBOT ikhoza kukhala yofunikira pochiza ndi kupewa matenda omwe amayamba chifukwa cha tizilombo toyambitsa matenda tosagonjetseka mankhwala ambiri, zomwe zimakhala njira yofunika kwambiri pamene mankhwala opha tizilombo alephera. Kafukufuku wambiri wanena za zotsatira zazikulu za HBOT zopha tizilombo toyambitsa matenda pa mabakiteriya omwe amalimbana ndi matenda. Mwachitsanzo, gawo la HBOT la mphindi 90 pa 2 ATM linachepetsa kwambiri kukula kwa MRSA. Kuphatikiza apo, mu zitsanzo za chiŵerengero, HBOT yawonjezera mphamvu ya maantibayotiki osiyanasiyana motsutsana ndi matenda a MRSA. Malipoti atsimikizira kuti HBOT ndi yothandiza pochiza osteomyelitis yomwe imayambitsidwa ndi Klebsiella pneumoniae yopangidwa ndi OXA-48 popanda kufunikira maantibayotiki ena aliwonse othandizira.
Mwachidule, chithandizo cha okosijeni wa hyperbaric chikuyimira njira yosiyana siyana yowongolera matenda, kukulitsa chitetezo cha mthupi komanso kukulitsa mphamvu ya mankhwala ophera majeremusi omwe alipo. Ndi kafukufuku wathunthu ndi chitukuko, ili ndi kuthekera kochepetsa zotsatira za kukana maantibayotiki, kupereka chiyembekezo pankhondo yomwe ikupitilira yolimbana ndi matenda a mabakiteriya.
Nthawi yotumizira: Feb-28-2025