M'malo amankhwala amakono, maantibayotiki atsimikizira kuti ndi chimodzi mwazofunikira kwambiri, ndikuchepetsa kwambiri kuchuluka kwa anthu omwe amafa ndi matenda oyambitsidwa ndi tizilombo tating'onoting'ono. Kukhoza kwawo kusintha zotsatira zachipatala za matenda a bakiteriya kwawonjezera nthawi ya moyo wa odwala osawerengeka. Maantibayotiki ndi ofunikira pazachipatala zovuta, kuphatikiza maopaleshoni, ma implants, transplants, ndi chemotherapy. Komabe, kubuka kwa tizilombo tosamva maantibayotiki kwakhala kuda nkhawa kwambiri, zomwe zikuchepetsa mphamvu ya mankhwalawa pakapita nthawi. Kukaniza kwa maantibayotiki kwalembedwa m'magulu onse a maantibayotiki pomwe kusintha kwa ma virus kumachitika. Kukakamiza kwa kusankha komwe kumapangidwa ndi mankhwala oletsa tizilombo toyambitsa matenda kwathandizira kukwera kwa mitundu yosamva, zomwe zikubweretsa vuto lalikulu ku thanzi ladziko lonse.
Pofuna kuthana ndi vuto lalikulu la kukana kwa antimicrobial, ndikofunikira kukhazikitsa njira zothana ndi matenda zomwe zimalepheretsa kufalikira kwa tizilombo toyambitsa matenda, komanso kuchepetsa kugwiritsa ntchito maantibayotiki. Komanso, pakufunika kwambiri njira zina zochiritsira. Hyperbaric Oxygen Therapy (HBOT) yakhala ikuwoneka ngati njira yodalirika m'nkhani ino, yomwe imaphatikizapo kutulutsa mpweya wa 100% pamagulu opanikizika kwa nthawi ndithu. Pokhala ngati chithandizo choyambirira kapena chowonjezera cha matenda, HBOT ingapereke chiyembekezo chatsopano chochiza matenda owopsa oyambitsidwa ndi tizilombo tosamva maantibayotiki.
Thandizoli limagwiritsidwa ntchito kwambiri ngati chithandizo choyambirira kapena china pazikhalidwe zosiyanasiyana, kuphatikiza kutupa, poizoni wa carbon monoxide, mabala osatha, matenda a ischemic, ndi matenda. Ntchito zachipatala za HBOT pochiza matenda ndizozama, zomwe zimapereka zabwino zambiri kwa odwala.
Ntchito Zachipatala za Hyperbaric Oxygen Therapy mu Infection
Umboni wamakono umathandizira kwambiri kugwiritsa ntchito HBOT, monga chithandizo chodziyimira pawokha komanso chothandizira, kupereka phindu lalikulu kwa odwala omwe ali ndi kachilombo. Panthawi ya HBOT, kuthamanga kwa okosijeni wamagazi kumatha kukwera mpaka 2000 mmHg, ndipo zotsatira zake zimakhala zapamwamba kwambiri za oxygen-tissue gradient zimatha kukweza kuchuluka kwa okosijeni wa minofu mpaka 500 mmHg. Zotsatira zotere ndizofunika kwambiri polimbikitsa kuchira kwa mayankho otupa komanso kusokonezeka kwa microcirculatory komwe kumawonedwa m'malo a ischemic, komanso kuyang'anira ma compartment syndrome.
HBOT imathanso kukhudza mikhalidwe yodalira chitetezo chamthupi. Kafukufuku akuwonetsa kuti HBOT imatha kupondereza ma syndromes a autoimmune ndi mayankho a chitetezo chamthupi omwe amapangidwa ndi antigen, kuthandizira kusunga kulolerana kwa graft pochepetsa kufalikira kwa ma lymphocyte ndi leukocytes ndikuwongolera mayankho a chitetezo chamthupi. Kuphatikiza apo, HBOTamathandizira machiritsomu zotupa zosatha pakhungu polimbikitsa angiogenesis, njira yofunika kwambiri yochira bwino. Mankhwalawa amalimbikitsanso mapangidwe a collagen matrix, gawo lofunikira pakuchiritsa mabala.
Chisamaliro chapadera chiyenera kuperekedwa ku matenda ena, makamaka matenda ozama komanso ovuta kuchiza monga necrotizing fasciitis, osteomyelitis, matenda osachiritsika a minofu yofewa, ndi matenda opatsirana a endocarditis. Chimodzi mwazachipatala chodziwika bwino cha HBOT ndi matenda akhungu ofewa komanso osteomyelitis omwe amalumikizidwa ndi milingo yotsika ya okosijeni yomwe nthawi zambiri imayambitsidwa ndi mabakiteriya a anaerobic kapena osamva.
1. Matenda a Diabetes Phazi
Phazi la matenda ashugazilonda zam'mimba ndizovuta kwambiri pakati pa odwala matenda ashuga, zomwe zimakhudza 25% ya anthu onsewa. Matendawa amapezeka kawirikawiri m'zilondazi (kuwerengera 40% -80% ya milandu) ndipo amachititsa kuti anthu azidwala komanso kufa. Matenda a diabetesic phazi (DFIs) nthawi zambiri amakhala ndi matenda a polymicrobial omwe amazindikiridwa ndi tizilombo toyambitsa matenda osiyanasiyana. Zinthu zosiyanasiyana, kuphatikiza kuwonongeka kwa ntchito ya fibroblast, zovuta zamapangidwe a collagen, njira zoteteza thupi ku ma cell, ndi ntchito ya phagocyte, zitha kulepheretsa kuchira kwa zilonda kwa odwala matenda ashuga. Kafukufuku wambiri wapeza kuti kuperewera kwa okosijeni wapakhungu kumakhala pachiwopsezo chachikulu chodulidwa ziwalo zokhudzana ndi ma DFI.
Monga imodzi mwazosankha zamakono za chithandizo cha DFI, HBOT yanenedwa kuti imathandizira kwambiri machiritso a zilonda zam'mimba za matenda a shuga, kenako kuchepetsa kufunika kodulidwa ndi njira zovuta zopangira opaleshoni. Sizimangochepetsa kufunikira kwa njira zogwiritsa ntchito kwambiri, monga maopaleshoni a nthiti ndi kumezanitsa khungu, komanso zimapereka ndalama zotsika komanso zotsatira zake zochepa poyerekeza ndi maopaleshoni. Kafukufuku wopangidwa ndi Chen et al. adawonetsa kuti magawo opitilira 10 a HBOT adathandizira kusintha kwa 78.3% pakuchiritsa mabala kwa odwala matenda ashuga.
2. Necrotizing Soft Tissue Infections
Matenda a necrotizing soft tissues (NSTIs) nthawi zambiri amakhala a polymicrobial, omwe amayamba chifukwa cha kuphatikiza kwa mabakiteriya a aerobic ndi anaerobic ndipo nthawi zambiri amagwirizana ndi kupanga mpweya. Ngakhale kuti ma NSTIs ndi osowa, amapereka chiwopsezo chachikulu cha kufa chifukwa cha kupita patsogolo kwawo mwachangu. Kuzindikira ndi kulandira chithandizo panthaŵi yake ndi koyenera ndikofunika kwambiri kuti tipeze zotsatira zabwino, ndipo HBOT yalimbikitsidwa ngati njira yowonjezera yothandizira matenda a NSTI. Ngakhale pali mikangano yokhudzana ndi kugwiritsidwa ntchito kwa HBOT mu NSTIs chifukwa cha kusowa kwa maphunziro omwe akuyembekezeka kuyendetsedwa,Umboni ukuwonetsa kuti zitha kukhala zogwirizana ndi kuchuluka kwa kupulumuka komanso kusungidwa kwa ziwalo mwa odwala NSTI.. Kafukufuku wam'mbuyo adawonetsa kuchepa kwakukulu kwa ziwopsezo zakufa pakati pa odwala NSTI omwe amalandila HBOT.
1.3 Matenda Opangira Opaleshoni
Ma SSI amatha kugawidwa potengera malo omwe ali ndi kachilomboka ndipo amatha kuchokera ku tizilombo toyambitsa matenda osiyanasiyana, kuphatikiza mabakiteriya a aerobic ndi anaerobic. Ngakhale kupita patsogolo kwa njira zopewera matenda, monga njira zoletsa kubereka, kugwiritsa ntchito maantibayotiki a prophylactic, komanso kupititsa patsogolo kachitidwe ka opaleshoni, ma SSI akadali vuto losalekeza.
Ndemanga imodzi yofunika yafufuza mphamvu ya HBOT popewa ma SSIs akuzama mu opaleshoni ya neuromuscular scoliosis. Preoperative HBOT ikhoza kuchepetsa kwambiri zochitika za SSIs ndikuthandizira kuchira kwa bala. Thandizo losawonongekali limapanga malo omwe mpweya wa okosijeni m'matumbo a bala umakhala wokwezeka, zomwe zakhala zikugwirizana ndi zomwe zimapha oxidative motsutsana ndi tizilombo toyambitsa matenda. Kuphatikiza apo, imayang'anira kuchepa kwa magazi ndi okosijeni omwe amathandizira kuti ma SSI apangidwe. Kupitilira njira zina zothanirana ndi matenda, HBOT yalimbikitsidwa makamaka pochita maopaleshoni opanda matenda monga njira zopangira ma colorectal.
1.4 Kuwotcha moto
Kuwotcha ndi kuvulala komwe kumachitika chifukwa cha kutentha kwambiri, mphamvu yamagetsi, mankhwala, kapena ma radiation ndipo kungayambitse matenda ambiri komanso kufa. HBOT imapindulitsa pochiza zowotcha powonjezera milingo ya okosijeni m'matenda owonongeka. Ngakhale maphunziro a zinyama ndi azachipatala amapereka zotsatira zosiyana zokhudzana ndimphamvu ya HBOT pakuwotcha, kafukufuku wokhudza odwala 125 omwe amawotcha adawonetsa kuti HBOT sinawonetsere kuti anthu amafa kwambiri kapena kuchuluka kwa maopaleshoni omwe adachitidwa koma adachepetsa nthawi ya machiritso (masiku 19.7 poyerekeza ndi masiku 43.8). Kuphatikiza HBOT ndi kasamalidwe kokwanira kawotcha kumatha kuwongolera bwino sepsis mwa odwala omwe amawotcha, zomwe zimatsogolera kufupikitsa machiritso ndikuchepetsa zofunikira zamadzimadzi. Komabe, kafukufuku wowonjezereka woyembekezeredwa akufunika kuti atsimikizire udindo wa HBOT pakuwongolera kuyatsa kwakukulu.
1.5 Osteomyelitis
Osteomyelitis ndi matenda a mafupa kapena mafupa omwe nthawi zambiri amayamba chifukwa cha tizilombo toyambitsa matenda. Kuchiza osteomyelitis kungakhale kovuta chifukwa cha kuchepa kwa magazi m'mafupa komanso kuchepa kwa maantibayotiki m'mafupa. Chronic osteomyelitis imadziwika ndi tizilombo toyambitsa matenda, kutupa pang'ono, ndi mapangidwe a necrotic fupa. Refractory osteomyelitis imatanthawuza matenda osachiritsika a mafupa omwe amapitirira kapena kubwereranso ngakhale atalandira chithandizo choyenera.
HBOT yawonetsedwa kuti imathandizira kwambiri mpweya wa okosijeni m'mafupa omwe ali ndi kachilomboka. Zambiri zotsatizana ndi kafukufuku wamagulu akuwonetsa kuti HBOT imakulitsa zotsatira zachipatala kwa odwala osteomyelitis. Zikuwoneka kuti zimagwira ntchito m'njira zosiyanasiyana, kuphatikiza kulimbikitsa ntchito za metabolic, kupondereza tizilombo toyambitsa matenda, kukulitsa zotsatira za maantibayotiki, kuchepetsa kutupa, komanso kulimbikitsa machiritso.njira. Pambuyo pa HBOT, 60% mpaka 85% ya odwala omwe ali ndi matenda osachiritsika, osteomyelitis amawonetsa zizindikiro za kuponderezedwa kwa matenda.
1.6 Matenda a fungal
Padziko lonse lapansi, anthu opitilira 3 miliyoni amadwala matenda oyamba ndi fungus, zomwe zimapangitsa kuti anthu opitilira 600,000 amafa chaka chilichonse. Zotsatira za chithandizo cha matenda oyamba ndi fungus nthawi zambiri zimasokonekera chifukwa cha zinthu monga kusintha kwa chitetezo chamthupi, matenda oyamba, komanso mawonekedwe a tizilombo toyambitsa matenda. HBOT ikukhala njira yabwino yochizira matenda oyamba ndi mafangasi chifukwa chachitetezo chake komanso chosasokoneza. Kafukufuku akuwonetsa kuti HBOT ikhoza kukhala yothandiza polimbana ndi tizilombo toyambitsa matenda monga Aspergillus ndi Mycobacterium tuberculosis.
HBOT imalimbikitsa zotsatira za antifungal poletsa mapangidwe a biofilm a Aspergillus, ndikuwonjezereka kwabwino komwe kumadziwika mu mitundu yopanda ma jini a superoxide dismutase (SOD). Mikhalidwe ya hypoxic pa nthawi ya matenda a mafangasi imabweretsa zovuta pakubweretsa mankhwala oletsa kubereka, kupangitsa kuchuluka kwa okosijeni kuchokera ku HBOT kukhala njira yothandiza, ngakhale kafukufuku wina akuyenera.
The Antimicrobial Properties of HBOT
Malo a hyperoxic opangidwa ndi HBOT amayambitsa kusintha kwa thupi ndi biochemical komwe kumapangitsa kuti tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda tizilombo toyambitsa matenda zitheke. HBOT imawonetsa zotsatira zochititsa chidwi motsutsana ndi mabakiteriya a aerobic ndipo makamaka mabakiteriya a anaerobic kudzera m'makina monga zochitika zachindunji za bactericidal, kupititsa patsogolo mayankho a chitetezo chamthupi, ndi zotsatira za synergistic ndi antimicrobial agents.
2.1 Direct Antibacterial Effects ya HBOT
Mphamvu ya antibacterial yachindunji ya HBOT makamaka imachokera ku mtundu wa reactive oxygen mitundu (ROS), yomwe imaphatikizapo superoxide anions, hydrogen peroxide, hydroxyl radicals, ndi hydroxyl ions-zonse zomwe zimachitika panthawi ya metabolism.
Kuyanjana pakati pa O₂ ndi zigawo zama cell ndikofunikira pakumvetsetsa momwe ROS imapangidwira m'maselo. Pazifukwa zina zomwe zimatchedwa kupsinjika kwa okosijeni, mgwirizano pakati pa mapangidwe a ROS ndi kuwonongeka kwake kumasokonekera, zomwe zimapangitsa kuti ROS ikhale yokwera m'maselo. Kupanga kwa superoxide (O₂⁻) kumapangidwa ndi superoxide dismutase, yomwe pambuyo pake imasintha O₂⁻ kukhala hydrogen peroxide (H₂O₂). Kutembenukaku kumakulitsidwanso ndi machitidwe a Fenton, omwe amawonjezera Fe²⁺ kuti apange ma hydroxyl radicals (·OH) ndi Fe³⁺, motero kumayambitsa kutsatizana kowononga redox kapangidwe ka ROS ndi kuwonongeka kwa ma cellular.
Zotsatira zapoizoni za ROS zimayang'ana zigawo zofunika kwambiri zama cell monga DNA, RNA, mapuloteni, ndi lipids. Makamaka, DNA ndiye chandamale chachikulu cha H₂O₂-mediated cytotoxicity, chifukwa imasokoneza mapangidwe a deoxyribose ndikuwononga zoyambira. Kuwonongeka kwakuthupi komwe kumayambitsidwa ndi ROS kumafikira ku mawonekedwe a helix a DNA, mwina chifukwa cha lipid peroxidation yoyambitsidwa ndi ROS. Izi zikugogomezera zotsatira zoyipa za kuchuluka kwa ROS mkati mwazinthu zachilengedwe.
Antimicrobial Action ya ROS
ROS imagwira ntchito yofunika kwambiri poletsa kukula kwa tizilombo tating'onoting'ono, monga momwe zikuwonekera kudzera mumbadwo wa ROS wopangidwa ndi HBOT. Zowopsa za ROS zimayang'ana mwachindunji zigawo zama cell monga DNA, mapuloteni, ndi lipids. Mitundu yambiri ya okosijeni yogwira ntchito imatha kuwononga lipids mwachindunji, zomwe zimapangitsa kuti lipid peroxidation. Izi zimasokoneza kukhulupirika kwa nembanemba zama cell ndipo, chifukwa chake, magwiridwe antchito a ma membrane-associated receptors ndi mapuloteni.
Kuphatikiza apo, mapuloteni, omwenso ndi mamolekyu ofunika kwambiri a ROS, amasinthidwa mwapadera ndi zotsalira za amino acid monga cysteine, methionine, tyrosine, phenylalanine, ndi tryptophan. Mwachitsanzo, HBOT yasonyezedwa kuti imapangitsa kusintha kwa okosijeni m'mapuloteni angapo a E. coli, kuphatikizapo elongation factor G ndi DnaK, motero amakhudza ntchito zawo zama cell.
Kupititsa patsogolo Chitetezo Kudzera mu HBOT
Zotsutsana ndi zotupa za HBOTzalembedwa, zomwe zikuwonetsa kuti ndizofunikira kwambiri kuti zichepetse kuwonongeka kwa minofu ndi kupondereza kufalikira kwa matenda. HBOT imakhudza kwambiri kufotokozera kwa ma cytokines ndi zowongolera zina zotupa, zomwe zimakhudza kuyankha kwa chitetezo chamthupi. Machitidwe osiyanasiyana oyesera adawona kusintha kosiyana kwa mafotokozedwe a jini ndi kupanga mapuloteni pambuyo pa HBOT, omwe amawongolera kapena kuchepetsa kukula ndi ma cytokines.
Panthawi ya HBOT, kuchuluka kwa O₂ kumayambitsa mayankho osiyanasiyana am'manja, monga kupondereza kutulutsidwa kwa oyimira zotupa komanso kulimbikitsa ma lymphocyte ndi neutrophil apoptosis. Zonsezi, izi zimapangitsa kuti chitetezo cha mthupi chitetezeke, potero zimathandizira kuchira kwa matenda.
Kuphatikiza apo, kafukufuku akuwonetsa kuti kuchuluka kwa O₂ pa HBOT kumatha kuchepetsa kuwonetsa kwa ma cytokines oyambitsa kutupa, kuphatikiza interferon-gamma (IFN-γ), interleukin-1 (IL-1), ndi interleukin-6 (IL-6). Zosinthazi zikuphatikizanso kuchepetsa chiŵerengero cha CD4: CD8 T maselo ndi kusintha ma receptor ena osungunuka, pamapeto pake kukweza ma interleukin-10 (IL-10), omwe ndi ofunikira kwambiri polimbana ndi kutupa ndi kulimbikitsa machiritso.
Ntchito za antimicrobial za HBOT zimalumikizana ndi njira zovuta zamoyo. Zonse ziwiri za superoxide ndi kuthamanga kokwezeka kwanenedwa kuti kumalimbikitsa mosagwirizana ndi HBOT-induced antibacterial activation ndi neutrophil apoptosis. Kutsatira HBOT, kukwera kwakukulu kwa mpweya wa okosijeni kumakulitsa mphamvu za bakiteriya za neutrophils, gawo lofunikira la chitetezo chamthupi. Kuphatikiza apo, HBOT imapondereza kuphatikiza kwa neutrophil, komwe kumalumikizidwa ndi kuyanjana kwa β-integrins pa neutrophils ndi ma intercellular adhesion molecules (ICAM) pama cell endothelial. HBOT imalepheretsa ntchito ya neutrophil β-2 integrin (Mac-1, CD11b / CD18) kupyolera mu ndondomeko ya nitric oxide (NO), yomwe imathandizira kusamuka kwa neutrophils kupita kumalo opatsirana.
Kukonzekera bwino kwa cytoskeleton ndikofunikira kuti ma neutrophils athe phagocytize tizilombo toyambitsa matenda. S-nitrosylation ya actin yasonyezedwa kuti imalimbikitsa actin polymerization, zomwe zingathe kutsogolera ntchito ya phagocytic ya neutrophils pambuyo pa chithandizo cha HBOT chisanachitike. Kuphatikiza apo, HBOT imalimbikitsa apoptosis m'mizere ya T cell yamunthu kudzera munjira za mitochondrial, ndi kufa kwa ma lymphocyte pambuyo pa HBOT. Kuletsa caspase-9-popanda kukhudza caspase-8-kwawonetsa zotsatira za immunomodulatory za HBOT.
Ma Synergistic Effects a HBOT okhala ndi Antimicrobial Agents
Pazachipatala, HBOT imagwiritsidwa ntchito pafupipafupi limodzi ndi maantibayotiki kuti athane ndi matenda moyenera. Mkhalidwe wa hyperoxic womwe umapezeka mu HBOT ukhoza kukhudza mphamvu ya maantibayotiki ena. Kafukufuku akuwonetsa kuti mankhwala enaake ophera mabakiteriya, monga β-lactam, fluoroquinolones, ndi aminoglycosides, samangogwiritsa ntchito njira zachibadwa komanso amadalira pang'ono kagayidwe ka aerobic ka bakiteriya. Chifukwa chake, kupezeka kwa okosijeni ndi mawonekedwe a kagayidwe kachakudya a tizilombo toyambitsa matenda ndikofunikira powunika machiritso a maantibayotiki.
Umboni wambiri wasonyeza kuti mpweya wochepa wa okosijeni ukhoza kuonjezera kukana kwa Pseudomonas aeruginosa ku piperacillin/tazobactam komanso kuti malo otsika a oxygen amathandizanso kuti Enterobacter cloacae ikhale yolimba ku azithromycin. Kumbali ina, mikhalidwe ina ya hypoxic imatha kukulitsa chidwi cha bakiteriya ku maantibayotiki a tetracycline. HBOT imagwira ntchito ngati njira yochiritsira yothandiza poyambitsa kagayidwe ka aerobic ndi reoxygenating minyewa yomwe ili ndi kachilombo ka hypoxic, kenako ndikuwonjezera chidwi cha tizilombo toyambitsa matenda.
M'maphunziro a preclinical, kuphatikiza kwa HBOT-kuperekedwa kawiri tsiku lililonse kwa maola 8 pa 280 kPa-pamodzi ndi tobramycin (20 mg/kg/tsiku) kunachepetsa kwambiri kuchuluka kwa mabakiteriya mu Staphylococcus aureus infectious endocarditis. Izi zikuwonetsa kuthekera kwa HBOT ngati chithandizo chothandizira. Kufufuza kwina kwawonetsa kuti pansi pa 37 ° C ndi 3 ATA kupanikizika kwa maola 5, HBOT imapangitsa kuti imipenem ikhale ndi macrophage-infected Pseudomonas aeruginosa. Kuonjezera apo, njira yophatikizana ya HBOT ndi cephalolin inapezeka kuti ndi yothandiza kwambiri pochiza Staphylococcus aureus osteomyelitis mu zitsanzo za nyama poyerekeza ndi cephalzolin yokha.
HBOT imawonjezeranso kwambiri mphamvu ya bactericidal ya ciprofloxacin motsutsana ndi Pseudomonas aeruginosa biofilms, makamaka kutsatira mphindi 90 zakuwonekera. Kupititsa patsogolo kumeneku kumabwera chifukwa cha mapangidwe amtundu wa okosijeni wa endogenous reactive oxygen (ROS) ndipo amawonetsa kukhudzika kochulukira muzosintha za peroxidase-defective.
Mu zitsanzo za pleuritis yoyambitsidwa ndi methicillin-resistant Staphylococcus aureus (MRSA), zotsatira zogwira ntchito za vancomycin, teicoplanin, ndi linezolid ndi HBOT zinawonetsa kwambiri kuwonjezeka kwa mphamvu motsutsana ndi MRSA. Metronidazole, mankhwala opha tizilombo omwe amagwiritsidwa ntchito kwambiri pochiza matenda oopsa a anaerobic ndi polymicrobial monga matenda a diabetesic phazi (DFIs) ndi matenda opangira opaleshoni (SSIs), awonetsa mphamvu zambiri za antimicrobial pansi pamikhalidwe ya anaerobic. Kafukufuku wamtsogolo akuyenera kufufuza zotsatira za synergistic antibacterial za HBOT kuphatikizapo metronidazole mu vivo ndi mu vitro.
Mphamvu ya Antimicrobial ya HBOT pa Mabakiteriya Osagwirizana
Ndi chisinthiko ndi kufalikira kwa mitundu yosamva, maantibayotiki achikhalidwe nthawi zambiri amataya mphamvu pakapita nthawi. Kuphatikiza apo, HBOT ikhoza kukhala yofunikira pochiza ndi kupewa matenda omwe amayamba chifukwa cha tizilombo tosamva mankhwala ambiri, zomwe zimakhala ngati njira yofunika kwambiri chithandizo chamankhwala chikalephera. Kafukufuku wambiri wanena za zotsatira zazikulu za bactericidal za HBOT pa mabakiteriya olimbana ndi matenda. Mwachitsanzo, gawo la HBOT la mphindi 90 pa ATM 2 linachepetsa kwambiri kukula kwa MRSA. Kuphatikiza apo, mumitundu yachiyerekezo, HBOT yawonjezera zotsatira za antibacterial za maantibayotiki osiyanasiyana motsutsana ndi matenda a MRSA. Malipoti atsimikizira kuti HBOT ndi yothandiza pochiza osteomyelitis chifukwa cha OXA-48-kupanga Klebsiella pneumoniae popanda kufunikira mankhwala ophatikizira.
Mwachidule, chithandizo cha okosijeni cha hyperbaric chimayimira njira zambiri zothanirana ndi matenda, kupititsa patsogolo chitetezo chamthupi komanso kukulitsa mphamvu ya ma antimicrobial omwe alipo. Ndi kafukufuku wathunthu ndi chitukuko, imakhala ndi kuthekera kochepetsera zotsatira za kukana kwa maantibayotiki, kupereka chiyembekezo pankhondo yolimbana ndi matenda a bakiteriya.
Nthawi yotumiza: Feb-28-2025